Comparison 1. Individual NSAID versus placebo.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Clinical success	29		Risk Ratio (M‐H, Fixed, 95% CI)	Subtotals only
1.1 Diclofenac	10	2050	Risk Ratio (M‐H, Fixed, 95% CI)	1.60 [1.49, 1.72]
1.2 Ibuprofen	5	436	Risk Ratio (M‐H, Fixed, 95% CI)	1.64 [1.33, 2.01]
1.3 Ketoprofen	7	683	Risk Ratio (M‐H, Fixed, 95% CI)	1.56 [1.37, 1.77]
1.4 Piroxicam	3	504	Risk Ratio (M‐H, Fixed, 95% CI)	1.48 [1.27, 1.73]
1.5 Indomethacin	3	341	Risk Ratio (M‐H, Fixed, 95% CI)	1.26 [1.03, 1.55]
1.6 Benzydamine	3	193	Risk Ratio (M‐H, Fixed, 95% CI)	1.15 [0.96, 1.38]
2 Local adverse events	33		Risk Ratio (M‐H, Fixed, 95% CI)	Subtotals only
2.1 Diclofenac	15	3271	Risk Ratio (M‐H, Fixed, 95% CI)	0.78 [0.56, 1.10]
2.2 Ibuprofen	3	321	Risk Ratio (M‐H, Fixed, 95% CI)	2.30 [0.98, 5.43]
2.3 Ketoprofen	8	852	Risk Ratio (M‐H, Fixed, 95% CI)	1.19 [0.83, 1.70]
2.4 Piroxicam	3	522	Risk Ratio (M‐H, Fixed, 95% CI)	0.42 [0.17, 1.08]
2.5 Felbinac	3	397	Risk Ratio (M‐H, Fixed, 95% CI)	1.91 [0.49, 7.50]
2.6 Indomethacin	3	354	Risk Ratio (M‐H, Fixed, 95% CI)	2.65 [0.91, 7.73]