Comparison 5. All topical NSAIDs versus placebo.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Local adverse events	42	6740	Risk Ratio (M‐H, Fixed, 95% CI)	0.98 [0.80, 1.21]
2 Systemic adverse events	36	5576	Risk Ratio (M‐H, Fixed, 95% CI)	0.96 [0.73, 1.26]
3 Adverse event withdrawals	42	6405	Risk Ratio (M‐H, Fixed, 95% CI)	1.01 [0.64, 1.59]