Study |
Drug |
Concentration |
Quantity |
Frequency |
Estimated daily dose of topical NSAID |
Joussellin 2003 |
Diclofenac |
1% |
Plaster |
1 |
180 mg epolamine salt, 140 mg Na salt |
Li 2013 |
Diclofenac |
1% |
Plaster |
2 |
360 mg epolamine salt, 280 mg Na salt |
Rowbotham 2003 |
Diclofenac |
1% |
Plaster |
2 |
360 mg epolamine salt, 280 mg Na salt |
Saillant 1998 |
Diclofenac |
1% |
Plaster |
1 |
180 mg epolamine salt, 140 mg Na salt |
Coudreuse 2010 |
Diclofenac |
1% |
Plaster |
1 |
180 mg epolamine salt, 140 mg Na salt |
Klainguti 2010 |
Diclofenac |
1% |
Plaster |
1 |
180 mg epolamine salt, 140 mg Na salt |
Predel 2004 |
Diclofenac |
‐ |
Plaster |
2 |
280 mg Na salt |
Predel 2012 |
Diclofenac |
2.32% |
5 cm ribbon/˜ 2 g |
2 or 3 |
92‐138 mg (?Na equiv) as diethylamine salt |
Predel 2013b |
Diclofenac |
1.16% |
2 g |
4 |
92 mg (?Na equiv) as diethylamine salt |
Predel 2013a |
Diclofenac |
4% |
4‐5 sprays |
3 |
96‐120 mg Na salt |
Costantino 2011 |
Diclofenac |
1% |
Plaster |
1 |
180 mg epolamine salt, 140 mg Na salt |
Fioravanti 1999 |
Diclofenac |
‐ |
5 g |
3 |
195 mg epolamine salt |
Gallacchi 1990 |
Diclofenac |
1% |
2 g |
4 |
80 mg |
González de Vega 2013 |
Diclofenac |
1% |
6 cm, 2g |
3 |
60 mg |
Hoffmann 2012 |
Diclofenac |
1% |
Plaster |
1 |
180 mg epolamine salt, 140 mg Na salt |
Hofman 2000 |
Diclofenac |
1% |
2 cm |
4 |
probably 30‐40 mg Na salt |
Jenoure 1997 |
Diclofenac |
1% |
Plaster |
2 |
360 mg epolamine salt, 280 mg Na salt |
Mahler 2003 |
Diclofenac |
‐ |
5 g |
3 |
195 mg epolamine salt |
NCT01255423 |
Diclofenac |
1% |
‐ |
4 |
‐ |
NCT01272934 |
Diclofenac |
1% |
‐ |
4 |
‐ |
NCT01272947 |
Diclofenac |
1% |
‐ |
4 |
‐ |
Spacca 2005 |
Diclofenac |
‐ |
5 g |
3 |
195 mg epolamine salt |
Campbell 1994 |
Ibuprofen |
5% |
4 inch ribbon |
4 |
Assume 800 mg |
Dreiser 1988 |
Ibuprofen |
5% |
4 cm ribbon
(10 cm for larger joints) |
4 |
Assume up‐800 mg |
Ramesh 1983 |
Ibuprofen |
5% |
5‐10 cm ribbon |
3‐4 |
Assume 300‐800 mg |
Billigmann 1996 |
Ibuprofen |
5% |
10 cm, 4 g gel |
3 |
600 mg |
Machen 2002 |
Ibuprofen |
5% |
‐ |
3 |
‐ |
Picchio 1981 |
Ibuprofen |
10% |
‐ |
3 |
‐ |
Whitefield 2002 |
Ibuprofen |
5% |
‐ |
3 |
‐ |
Mazières 2005b |
Ketoprofen |
‐ |
Plaster |
1 |
100 mg |
Mazières 2005a |
Ketoprofen |
‐ |
Plaster |
1 |
100 mg |
Airaksinen 1993 |
Ketoprofen |
‐ |
5 g |
2 |
125 mg |
Dreiser 1989 |
Ketoprofen |
2.5% |
5 cm |
2 |
100 mg |
Julien 1989 |
Ketoprofen |
2.5% |
5 cm |
2 |
100 mg |
Noret 1987 |
Ketoprofen |
2.5% |
5 cm, 7.5 g |
2 |
375 mg |
Curioni 1985 |
Ketoprofen |
No details |
|
2 |
‐ |
Governali 1995 |
Ketoprofen |
5% |
2‐3 g |
3 |
300‐450 mg |
Governali 1995 |
Ketoprofen |
1% |
2‐3 g |
3 |
60‐90 mg |
Gualdi 1987 |
Ketoprofen |
‐ |
3‐5 cm |
2 |
‐ |
Kockelbergh 1985 |
Ketoprofen |
2.5% |
5 cm |
2 |
100 mg |
Parrini 1992 |
Ketoprofen |
15.0% |
2 g |
3 |
600 mg |
Picchio 1981 |
Ketoprofen |
1% |
‐ |
3 |
‐ |
Tonutti 1994 |
Ketoprofen |
5% |
2‐3 g |
3 |
300‐450 mg |
Ăkermark 1990 |
Indomethacin |
1% |
0.5‐1.5 mL |
3‐5 |
12‐60 mg |
Aoki 1984 |
Indomethacin |
1% |
1 g |
3‐4 |
30‐40 mg |
Fujimaki 1985 |
Indomethacin |
1% |
1 g |
3‐4 |
30‐40 mg |
Sugioka 1984 |
Indomethacin |
1% |
1 g |
3‐4 |
30‐40 mg |
Aoki 1984 |
Piroxicam |
0.5% |
1 g |
3‐4 |
15‐20 mg |
Fujimaki 1985 |
Piroxicam |
0.5% |
1 g |
3‐4 |
15‐20 mg |
Russell 1991 |
Piroxicam |
0.5% |
5 mg |
4 |
20 mg |
Sugioka 1984 |
Piroxicam |
0.5% |
1 g |
3‐4 |
15‐20 mg |
Chatterjee 1977 |
Benzydamine |
3% |
‐ |
3 |
‐ |
Haig 1986 |
Benzydamine |
3% |
‐ |
6 |
‐ |
Linde 1985 |
Benzydamine |
3% |
‐ |
3 |
‐ |
Auclair 1989 |
Niflumic acid |
2.5% |
10 cm, 5 g |
3 |
375 mg |
Dreiser 1990 |
Niflumic acid |
2.5% |
10 cm, 5 g |
3 |
375 mg |
Curioni 1985 |
Ibuproxam gel |
10% |
‐ |
2 |
‐ |
Curioni 1985 |
Etofenamate |
No details |
‐ |
2 |
‐ |
Diebshlag 1990 |
Etofenamate |
5% |
3 g |
3 |
450 mg |
Tonutti 1994 |
Etofenamate |
5% |
2‐3 g |
3 |
300‐450 mg |
Diebshlag 1990 |
Ketorolac |
2% |
3 g |
3 |
360 mg |
Dreiser 1994 |
Flurbiprofen |
Patch |
|
2 |
80 mg |
Gualdi 1987 |
Flunoxaprofen |
‐ |
3‐5 cm |
2 |
‐ |
Hofman 2000 |
Lysine clonixinate |
5% |
2 cm |
4 |
90 mg |
Hosie 1993 |
Felbinac |
3% |
2 g |
3 |
180 mg |
McLatchie 1989 |
Felbinac |
3% |
3 cm |
3 |
‐ |
Morris 1991 |
Felbinac |
3% |
1 cm |
3 |
‐ |
Sanguinetti 1989 |
Felbinac |
3% |
‐ |
3 |
‐ |
Sinniger 1981 |
Fentiazac |
5% |
Varied according to involved areas |
2‐3 |
‐ |
Thorling 1990 |
Naproxen |
10% |
‐ |
2‐6 |
‐ |
Vecchiet 1991 |
Meclofenamic acid |
5% |
10 cm, 4 g |
2 |
400 mg |
equiv: equivalent; Na: sodium. |