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. 2015 Jun 15;2015(6):CD007402. doi: 10.1002/14651858.CD007402.pub3

Coudreuse 2010.

Methods R, DB, PC, multicentre, parallel group
Plaster applied daily for 7 days
PI assessed twice daily over 3 days, then day 7. Overall treatment efficacy and tolerability assessed on days 3, 7
Participants Ankle sprain (< 48 hours) with lateral external ligament involvement
 PI on movement ≥ 50/100, oedema ≥ 20 mm difference between ankles
N = 240 (233 for analysis)
M 148, F 86, 6 unknown
Interventions DHEP/hep, n = 120
 Placebo, n = 120
Rescue medication: paracetamol to maximum 4 g daily
 No other treatments allowed
Outcomes Global efficacy at 7 days: 4‐point scale (responder = "excellent" or "good")
Mean change in PI on movement at 6 hours and 7 days
Mean change in oedema at 3 and 7 days
Tolerability
Adverse events
Withdrawals
Notes Oxford Quality Score: R2, DB2, W1. Total = 5/5
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Low risk Computer‐generated
Allocation concealment (selection bias) Unclear risk "sealed envelopes"
Blinding (performance bias and detection bias) 
 All outcomes Low risk Appearance and odour identical for all plasters
Incomplete outcome data (attrition bias) 
 All outcomes Low risk ITT analysis, < 5% excluded for missing data, equal between groups
Size Unclear risk 50 to 200 participants per treatment arm