Coudreuse 2010.

Methods	R, DB, PC, multicentre, parallel group Plaster applied daily for 7 days PI assessed twice daily over 3 days, then day 7. Overall treatment efficacy and tolerability assessed on days 3, 7
Participants	Ankle sprain (< 48 hours) with lateral external ligament involvement PI on movement ≥ 50/100, oedema ≥ 20 mm difference between ankles N = 240 (233 for analysis) M 148, F 86, 6 unknown
Interventions	DHEP/hep, n = 120 Placebo, n = 120 Rescue medication: paracetamol to maximum 4 g daily No other treatments allowed
Outcomes	Global efficacy at 7 days: 4‐point scale (responder = "excellent" or "good") Mean change in PI on movement at 6 hours and 7 days Mean change in oedema at 3 and 7 days Tolerability Adverse events Withdrawals
Notes	Oxford Quality Score: R2, DB2, W1. Total = 5/5
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	Computer‐generated
Allocation concealment (selection bias)	Unclear risk	"sealed envelopes"
Blinding (performance bias and detection bias) All outcomes	Low risk	Appearance and odour identical for all plasters
Incomplete outcome data (attrition bias) All outcomes	Low risk	ITT analysis, < 5% excluded for missing data, equal between groups
Size	Unclear risk	50 to 200 participants per treatment arm