Dreiser 1988.
Methods | R, DB, PC, parallel groups Cream applied 3 times daily Assessment at baseline, 7 days |
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Participants | Acute tendinitis (< 1 month) N = 64 M 35, F 25 Mean age 36 years Baseline spontaneous pain ≥ 60 mm |
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Interventions | Ibuprofen cream 5%, 3 x 4 cm daily, n = 32 (3 x 10 cm for large joints) Placebo cream, n = 32 No other topical, systemic, or physical treatment allowed |
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Outcomes | PGE: scale not reported (responder = "improvement" or "complete relief") Improvement in pain: VAS (mean data) Adverse events Withdrawals |
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Notes | Oxford Quality Score: R1, DB1, W1. Total = 3/5 Oxford Validity Score: 10/16 |
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Risk of bias | ||
Bias | Authors' judgement | Support for judgement |
Random sequence generation (selection bias) | Unclear risk | Not described |
Allocation concealment (selection bias) | Unclear risk | Not described |
Blinding (performance bias and detection bias) All outcomes | Unclear risk | Not described |
Incomplete outcome data (attrition bias) All outcomes | Low risk | Missing participants added back using BOCF |
Size | High risk | < 50 participants per treatment arm |