Dreiser 1988.

Methods	R, DB, PC, parallel groups Cream applied 3 times daily Assessment at baseline, 7 days
Participants	Acute tendinitis (< 1 month) N = 64 M 35, F 25 Mean age 36 years Baseline spontaneous pain ≥ 60 mm
Interventions	Ibuprofen cream 5%, 3 x 4 cm daily, n = 32 (3 x 10 cm for large joints) Placebo cream, n = 32 No other topical, systemic, or physical treatment allowed
Outcomes	PGE: scale not reported (responder = "improvement" or "complete relief") Improvement in pain: VAS (mean data) Adverse events Withdrawals
Notes	Oxford Quality Score: R1, DB1, W1. Total = 3/5 Oxford Validity Score: 10/16
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Not described
Allocation concealment (selection bias)	Unclear risk	Not described
Blinding (performance bias and detection bias) All outcomes	Unclear risk	Not described
Incomplete outcome data (attrition bias) All outcomes	Low risk	Missing participants added back using BOCF
Size	High risk	< 50 participants per treatment arm