González de Vega 2013.

Methods	R, DB (for gels), SB (for ointment), AC, multicentre, parallel groups 2 g (˜ 6 cm of gel) applied over injured area x 3 daily for 14 days Assessments at 0, 4, 7, 14 days of treatment, and day 42 follow‐up
Participants	Grade I or II ankle sprain (< 24 hours) with lateral external ligament involvement, PI on weight bearing ≥ 30/100 N = 449 M = 308, F = 112 (for analysis) Mean age 28 years
Interventions	Traumeel gel, 3 x 2 g daily, n = 140 Traumeel ointment, n = 143 (not analysed in this review) Diclofenac gel 1%, 3 x 2 g daily, n = 137 Rescue medication: paracetamol to maximum 2 g daily
Outcomes	Pain‐free on day 7 Global efficacy: 5‐point scale (responder = "good" and "very good") on day 14 Normal function on day 14: yes or no (responder = "yes") Adverse events Withdrawals
Notes	Oxford Quality Score: R2, DB2 (gels), W1. Total = 5/5
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	Computer‐generated
Allocation concealment (selection bias)	Low risk	Central allocation, kits assigned in order received, and used envelopes (no further details)
Blinding (performance bias and detection bias) All outcomes	Low risk	For gel comparison: "identical containers"
Incomplete outcome data (attrition bias) All outcomes	Unclear risk	Used LOCF. Most withdrawals due to early recovery (within 14 days), approximately equal between groups
Size	Unclear risk	50 to 200 participants per treatment arm