Governali 1995.

Methods	R, DB, AC, parallel groups Gel or cream applied 3 times daily for up to 14 days Assessed at baseline, 7, 14 days
Participants	Soft tissue injuries + 2 fractures N = 30 M = 21, F = 9 Median age 38 years Mean baseline pain on movement moderate to severe (2.8, scale 0 to 4)
Interventions	Ketoprofen gel 5%, 3 x 2 to 3 g daily, n = 15 Ketoprofen cream 1%, 3 x 2 to 3 g daily, n = 15
Outcomes	PGE: 5‐point scale (responder = "good" and "excellent") Adverse events Withdrawals
Notes	Oxford Quality Score: R1, DB1, W1. Total =3/5
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Not described
Allocation concealment (selection bias)	Unclear risk	Not described
Blinding (performance bias and detection bias) All outcomes	Unclear risk	Treatments were given in identical tubes and measurements made by blinded observers, but one was a cream and the other a gel
Incomplete outcome data (attrition bias) All outcomes	Low risk	All participants included in analysis
Size	High risk	< 50 participants per treatment arm