Joussellin 2003.

Methods	R, DB, PC, parallel groups Plaster applied to skin over affected area once daily Assessed at baseline, 1, 2, 3, 7 days
Participants	Ankle sprain (< 48 hours) N = 134 M 72, F 62 Age range 18 to 65 years Baseline spontaneous pain ≥ 50 mm
Interventions	DHEP plaster (Flector Tissugel 1%), x 1 daily, n = 68 Placebo plaster, x 1 daily, n = 66 Rescue medication: paracetamol
Outcomes	PGE: 4‐point scale (responder = "excellent") Pain on movement: VAS (mean) Adverse events Withdrawals
Notes	Oxford Quality Score: R1, DB2, W1. Total = 4/5
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Not described
Allocation concealment (selection bias)	Unclear risk	Not described
Blinding (performance bias and detection bias) All outcomes	Low risk	"Identical in size, appearance and used same formula as active patch, without active ingredient"
Incomplete outcome data (attrition bias) All outcomes	Low risk	All participants included in responder analysis
Size	Unclear risk	50 to 200 participants per treatment arm