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. 2015 Jun 15;2015(6):CD007402. doi: 10.1002/14651858.CD007402.pub3

Joussellin 2003.

Methods R, DB, PC, parallel groups
Plaster applied to skin over affected area once daily
Assessed at baseline, 1, 2, 3, 7 days
Participants Ankle sprain (< 48 hours)
N = 134
M 72, F 62
Age range 18 to 65 years
Baseline spontaneous pain ≥ 50 mm
Interventions DHEP plaster (Flector Tissugel 1%), x 1 daily, n = 68
Placebo plaster, x 1 daily, n = 66
Rescue medication: paracetamol
Outcomes PGE: 4‐point scale (responder = "excellent")
Pain on movement: VAS (mean)
Adverse events
Withdrawals
Notes Oxford Quality Score: R1, DB2, W1. Total = 4/5
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Unclear risk Not described
Allocation concealment (selection bias) Unclear risk Not described
Blinding (performance bias and detection bias) 
 All outcomes Low risk "Identical in size, appearance and used same formula as active patch, without active ingredient"
Incomplete outcome data (attrition bias) 
 All outcomes Low risk All participants included in responder analysis
Size Unclear risk 50 to 200 participants per treatment arm