McLatchie 1989.
Methods | R, DB, PC, parallel groups Gel applied to injured site 3 times daily for 7 days Assessment at baseline 4, 7 days at clinic, daily patient diary |
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Participants | Acute soft tissue injury (< 48 hours) N = 231 M 143, F 88 Mean age 33 years Baseline pain moderate to severe |
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Interventions | Felbinac gel 3%, 3 x 3 cm daily, n = 118 Placebo gel, 3 x 3 cm daily, n = 113 Rescue medication: paracetamol |
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Outcomes | Patient diary: mean change Adverse events Withdrawals |
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Notes | Oxford Quality Score: R1, DB2, W1. Total = 4/5 | |
Risk of bias | ||
Bias | Authors' judgement | Support for judgement |
Random sequence generation (selection bias) | Unclear risk | Not described |
Allocation concealment (selection bias) | Unclear risk | Not described |
Blinding (performance bias and detection bias) All outcomes | Low risk | "tubes identical in all aspects" |
Incomplete outcome data (attrition bias) All outcomes | Unclear risk | No usable efficacy data |
Size | Unclear risk | 50 to 200 participants per treatment arm |