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. 2015 Jun 15;2015(6):CD007402. doi: 10.1002/14651858.CD007402.pub3

Morris 1991.

Methods R, DB, PC, parallel groups
Gel applied to site of injury 3 times daily for 7 days
Assessed at baseline, 7 days at clinic, and daily patient diary
Participants Acute soft tissue injury (< 3 days)
N = 100 (84 analysed for efficacy)
M 70, F 14
Mean age 25 years
Baseline pain moderate to severe
Exclusions: 1 participant in placebo group lost to follow‐up, 15 protocol violations
Interventions Felbinac gel 3%, 3 x 1 cm daily, n = 41
Placebo gel, n = 43
Ice, joint immobilisation, bandaging and compression allowed
No concomitant oral NSAID, occlusive dressing, physiotherapy, or liniments allowed
Rescue medication: paracetamol
Outcomes PGE: 5‐point scale (responder = "good" and "very good")
Change in PI: patient diary 10 cm VAS (mean data)
Adverse events
Withdrawals and exclusions
Notes Oxford Quality Score: R1, DB2, W1. Total = 4/5
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Unclear risk Not described
Allocation concealment (selection bias) Low risk "Randomisation was undertaken at the production facility and a sealed copy of the list supplied to the investigator for reference, only in defined circumstances"
Blinding (performance bias and detection bias) 
 All outcomes Low risk "identical tubes and outer boxes", "placebo was a similarly constituted gel"
Incomplete outcome data (attrition bias) 
 All outcomes Low risk All relevant participants included in analysis
Size High risk < 50 participants per treatment arm