Noret 1987.

Methods	R, DB, PC parallel groups Gel applied twice daily for 7 days Assessment at baseline, 3, 8 days
Participants	Minor sports injuries (< 24 hours) N = 98 (93 analysed) M 71, F 27 Mean age 29 years Baseline pain > 60 mm
Interventions	Ketoprofen gel 2.5%, 2 x 5 cm daily (= 15 mg), n = 48 Placebo gel, n = 45 No other treatment given
Outcomes	PGE: 4‐point scale (responder = "good" and "excellent") Spontaneous pain: 100 mm VAS (mean data) Adverse events Withdrawals
Notes	Oxford Quality Score: R1, DB1, W1. Total = 3/5
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Not described
Allocation concealment (selection bias)	Low risk	"allocated according to a randomization list and a corresponding code in a sealed envelope"
Blinding (performance bias and detection bias) All outcomes	Unclear risk	Not described
Incomplete outcome data (attrition bias) All outcomes	Low risk	All participants included in analysis
Size	High risk	< 50 participants per treatment arm