Picchio 1981.
Methods | R, DB, AC, parallel groups Cream applied with slight massage until completely absorbed, 3 times daily for up to 16 days Assessed at baseline, 4, 8, 12, 16 days |
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Participants | Acute sports injuries N = 40 M 24, F 16 Mean age 22 years (range 12 to 46) Most participants had mild to moderate baseline pain (12 and 9 with slight pain on movement) |
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Interventions | Ibuprofen gel 10%, 3 x daily, n = 20 Ketoprofen gel 1%, 3 x daily, n = 20 |
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Outcomes | Pain on movement (responder = "none") Adverse events |
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Notes | Oxford Quality Score: R1, DB2, W0. Total = 3/5 | |
Risk of bias | ||
Bias | Authors' judgement | Support for judgement |
Random sequence generation (selection bias) | Unclear risk | Not described |
Allocation concealment (selection bias) | Unclear risk | Not described |
Blinding (performance bias and detection bias) All outcomes | Unclear risk | "tubes were identical in appearance" |
Incomplete outcome data (attrition bias) All outcomes | Low risk | All participants included in analysis |
Size | High risk | < 50 participants per treatment arm |