Picchio 1981.

Methods	R, DB, AC, parallel groups Cream applied with slight massage until completely absorbed, 3 times daily for up to 16 days Assessed at baseline, 4, 8, 12, 16 days
Participants	Acute sports injuries N = 40 M 24, F 16 Mean age 22 years (range 12 to 46) Most participants had mild to moderate baseline pain (12 and 9 with slight pain on movement)
Interventions	Ibuprofen gel 10%, 3 x daily, n = 20 Ketoprofen gel 1%, 3 x daily, n = 20
Outcomes	Pain on movement (responder = "none") Adverse events
Notes	Oxford Quality Score: R1, DB2, W0. Total = 3/5
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Not described
Allocation concealment (selection bias)	Unclear risk	Not described
Blinding (performance bias and detection bias) All outcomes	Unclear risk	"tubes were identical in appearance"
Incomplete outcome data (attrition bias) All outcomes	Low risk	All participants included in analysis
Size	High risk	< 50 participants per treatment arm