Sinniger 1981.

Methods	R, DB, PC, parallel groups Cream applied 2 to 3 times daily, with gentle massage, or if massage not possible (too painful) with protective dressing Assessment at baseline, 5, 10 days
Participants	Minor soft tissue injuries N = 20 M 11, F 9 Mean age 40 years Baseline pain not reported
Interventions	Fentiazac cream 5%, 2 to 3 x daily, n = 10 Placebo cream, 2 to 3 x daily, n = 10 All participants told to rest No other local and systemic treatments allowed Rescue medication: analgesic if actually needed
Outcomes	Pain relief: scale not reported (responder = total pain relief) % improvement in pain on movement: pain scale not reported (mean data) Adverse events
Notes	Oxford Quality Score: R1, DB1, W0. Total = 2/5
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Not described
Allocation concealment (selection bias)	Unclear risk	Not described
Blinding (performance bias and detection bias) All outcomes	Unclear risk	Not described
Incomplete outcome data (attrition bias) All outcomes	Low risk	All participants included in analysis
Size	High risk	< 50 participants per treatment arm