Sugioka 1984.

Methods	R, DB, AC, parallel groups Gel applied to affected area 3 to 4 times daily, without occlusion, for 14 days Assessed at baseline, 7, 14 days
Participants	Non‐traumatic diseases of muscle or tendon N = 366 (340 analysed for efficacy) M 115, F 202 (completers) Age range 12 to 84 years (most 30 to 70) Baseline pain on movement "none" or "mild" in about 1/3 of participants Exclusions for protocol violations: 8 piroxicam, 18 indomethacin
Interventions	Piroxicam gel 0.5%, 3 to 4 x 1 g daily, n = 183 Indomethacin gel 1%, 3 to 4 x 1 g daily, n = 183 No concomitant anti‐inflammatory or analgesic drug, including steroids, or initiation of physical therapy allowed
Outcomes	PGE: 5‐point scale (responder = "better" or "much better") Pain on movement: 4‐point scale (responder = "reduced" or "disappeared")
Notes	Oxford Quality Score: R1, DB2, W1. Total = 4/5
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Not described
Allocation concealment (selection bias)	Low risk	Key code sealed and retained until end of study
Blinding (performance bias and detection bias) All outcomes	Low risk	"both packages were of the same appearance and indistinguishable", and investigators did not see contents
Incomplete outcome data (attrition bias) All outcomes	Low risk	All relevant participants included in analysis
Size	Unclear risk	50 to 200 participants per treatment arm