Thorling 1990.

Methods	R, DB, PC, parallel groups Participants given specific instructions on how to apply gel (not reported) to affected area 2 to 6 times daily as required Assessment at baseline, 3, 7 days in clinic
Participants	Soft tissue injuries (< 48 hours) N = 120 M 85, F 35 Mean age 27 years Baseline pain moderate to severe
Interventions	Naproxen gel 10%, 2 to 6 x daily, n = 60 Placebo gel, 2 to 6 x daily, n = 60 Rescue medication: paracetamol 500 mg
Outcomes	PGE: 5‐point scale (responder = "good" and "very good") Pain on passive movement: 4‐point scale (mean data) Adverse events Withdrawals
Notes	Oxford Quality Score: R1, DB1, W1. Total = 3/5
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Not described
Allocation concealment (selection bias)	Unclear risk	Not described
Blinding (performance bias and detection bias) All outcomes	Low risk	"supplied in unmarked tubes"
Incomplete outcome data (attrition bias) All outcomes	Low risk	All participants included in analysis
Size	Unclear risk	50 to 200 participants per treatment arm