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. 2015 Jun 15;2015(6):CD007402. doi: 10.1002/14651858.CD007402.pub3

Thorling 1990.

Methods R, DB, PC, parallel groups
Participants given specific instructions on how to apply gel (not reported) to affected area 2 to 6 times daily as required
Assessment at baseline, 3, 7 days in clinic
Participants Soft tissue injuries (< 48 hours)
N = 120
M 85, F 35
Mean age 27 years
Baseline pain moderate to severe
Interventions Naproxen gel 10%, 2 to 6 x daily, n = 60
Placebo gel, 2 to 6 x daily, n = 60
Rescue medication: paracetamol 500 mg
Outcomes PGE: 5‐point scale (responder = "good" and "very good")
Pain on passive movement: 4‐point scale (mean data)
Adverse events
Withdrawals
Notes Oxford Quality Score: R1, DB1, W1. Total = 3/5
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Unclear risk Not described
Allocation concealment (selection bias) Unclear risk Not described
Blinding (performance bias and detection bias) 
 All outcomes Low risk "supplied in unmarked tubes"
Incomplete outcome data (attrition bias) 
 All outcomes Low risk All participants included in analysis
Size Unclear risk 50 to 200 participants per treatment arm