Tonutti 1994.

Methods	R, DB, AC, parallel groups Gel applied 3 times daily for 2 to 3 weeks Assessed at baseline, and intervals of 7 days
Participants	Muscle or joint trauma N = 30 M 20, F 10 Mean age 34 years 1 participant had injury of mild severity. Mean baseline pain on active movement 2.8 (scale 0 to 4)
Interventions	Ketoprofen gel 5%, 3 x 2 to 3 g daily, n = 15 Etofenamate gel 5%, 3 x 2 to 3 g, n = 15 No concomitant treatment with NSAID, aspirin, steroid or physical therapy
Outcomes	PGE: 4‐point scale (responder = "good" and "excellent") Pain on movement: 5‐point scale (mean data) Adverse events Withdrawals
Notes	Oxford Quality Score: R1, DB2, W1. Total = 4/5
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Not reported
Allocation concealment (selection bias)	Unclear risk	Not reported
Blinding (performance bias and detection bias) All outcomes	Low risk	"the two drugs were packed in indistinguishable tubes"
Incomplete outcome data (attrition bias) All outcomes	Low risk	All participants included in analysis
Size	High risk	< 50 participants per treatment arm