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| Methods | R, DB, PC, parallel groups |
| Participants | Acute ankle sprain, Grade I or II ≤ 24 hours. Age ≥ 16 years. Baseline PI ≥ 5/10 N = 305 |
| Interventions | Ibuprofen cream 200 mg in 2.7 g cream x 4 daily Placebo cream x 4 daily Treatment for 7 days |
| Outcomes | PI on movement daily to 7 days
PGE 7 days Systemic and local adverse events |
| Notes | Estimated completion January 2014. No results |
