Sarzi‐Puttini 2014.

Methods	R, DB, AC, parallel group, non‐inferiority study Duration 7 days
Participants	Acute musculoskeletal injury (mainly muscular, joint, tendon) N = 697 M 271, F 426 Mean age 52 years
Interventions	Ketoprofen (SKP‐021) patch, ketoprofen 30 mg Diclofenac (Voltadola), patch diclofenac sodium 140 mg Patches applied twice daily for 7 days
Outcomes	≥ 50% reduction in PI from baseline to end of study (100 mm VAS) Patient overall rating Clinical symptoms (4‐point scale) Time to response Adverse events, skin reactions Serious adverse events
Notes	"The analysis of the data of this trial showed that the two formulations were equally effective and well tolerated in the treatment of acute musculoskeletal injuries."

AC: active‐controlled; DB: double‐blind; F: female; M: male; N: number of participants in study; PC: placebo‐controlled; PGE: Patient Global Evaluation of treatment; PI: pain intensity; R: randomised; VAS: visual analogue scale.