Table 3:

Unadjusted Associations of Mental Illness With Endocrine Therapy Initiation, Discontinuation, Adherence

		Models
		Initiation		aDiscontinuation		bAdherence
Illness	Number with Illness	HR	p value	HR	p value	Estimate	p value
Any Mental Illness	5,459 (24.9%)	0.95 (0.92–0.98)	0.01	1.19 (1.11–1.27)	<.001	−0.006 (−0.012, 0.000)	0.06
Emotional Disorders:
Unipolar Depression	2,418 (11.0%)	0.95 (0.90–0.99)	0.03	1.09 (1.00–1.20)	0.06	−0.006 (−0.015, 0.002)	0.14
Anxiety	2,089 (9.5%)	1.00 (0.95–1.05)	0.87	1.24 (1.13–1.37)	<.001	−0.004 (−0.013, 0.005)	0.35
Adjustment	81 (0.4%)	0.93 (0.72–1.19)	0.56	1.42 (0.92–2.20)	0.12	−0.006 (−0.046, 0.034)	0.76
Cognitive Disorders:
Delirium	515 (2.4%)	0.85 (0.77–0.94)	0.01	1.14 (0.92–1.40)	0.23	0.009 (−0.009, 0.027)	0.32
Dementia	1,017 (4.6%)	0.82 (0.76–0.88)	<.001	1.10 (0.94–1.28)	0.25	0.008 (−0.005, 0.021)	0.20
Personality	59 (0.3%)	0.77 (0.56–1.07)	0.12	1.12 (0.61–2.09)	0.71	0.011 (−0.040, 0.061)	0.68
Mania and Psychoses:
Bipolar Depression	265 (1.2%)	0.85 (0.74–0.98)	0.02	0.95 (0.71–1.28)	0.75	−0.009 (−0.037, 0.019)	0.06
Schizophrenia	185 (0.8%)	0.99 (0.84–1.17)	0.94	0.81 (0.56–1.18)	0.28	0.035 (0.007, 0.062)	0.01
Non-Schizophrenia Psychosis	1,004 (4.6%)	0.89 (0.83–0.96)	0.01	1.20 (1.04–1.37)	0.01	−0.001 (−0.013, 0.012)	0.91
Substance Use:
Drug use	970 (4.4%)	0.99 (0.92–1.06)	0.69	1.40 (1.22–1.59)	<.001	−0.023(−0.038,−0.009)	0.002
Alcohol use	75 (0.3%)	1.01 (0.78–1.31)	0.96	1.71 (1.11–2.63)	0.01	−0.105 (−0.175,–0.034)	0.004

^aDiscontinuation analyzed for the first 5 years of endocrine therapy use.

^bProportion Days Covered (PDC) adherence was calculated in 1-year intervals, concluding after the 5th year of follow-up, if available. Individuals with less than 1 year of follow-up did not contribute to adherence values. Year adherence values not included if patient spent greater than half of that year hospitalized or in skilled nursing facilities. Adherence estimate of 0.01 corresponds to 1% change.