Table 2.
Statistically significant association between genotypes and risk of papillary thyroid cancer among whites (n=760).
| Chromosome | Gene name | SNP | Genotype | Cases | Controls | OR (95% CI) | P-value |
|---|---|---|---|---|---|---|---|
| 7 | HUS1 | rs2708896 | GG | 99 | 108 | 1 | |
| TG | 171 | 199 | 0.92(0.65–1.30) | 0.641180875 | |||
| TT | 63 | 120 | 0.55(0.36–0.83) | 0.004611807 | |||
| P for trend | 0.00570544 | ||||||
| TG & TT | 234 | 319 | 0.78(0.56–1.08) | 0.133937371 | |||
| 7 | HUS1 | rs10951937 | TT | 126 | 142 | 1 | |
| TG | 161 | 185 | 0.98(0.70–1.35) | 0.886392195 | |||
| GG | 46 | 100 | 0.51(0.33–0.79) | 0.002373343 | |||
| P for trend | 0.00704081 | ||||||
| GG & TG | 207 | 285 | 0.81(0.60–1.10) | 0.182937296 | |||
| 10 | MGMT | rs12769288 | CC | 276 | 317 | 1 | |
| TC | 55 | 101 | 0.62(0.43–0.90) | 0.012889857 | |||
| TT | 2 | 9 | 0.23(0.05–1.10) | 0.065342142 | |||
| P for trend | 0.0023066 | ||||||
| TC & TT | 57 | 110 | 0.59(0.41–0.85) | 0.004426897 | |||