Table 3.
Statistically significant association between genotypes and risk of papillary thyroid microcarcinoma among whites (n=590).
| Chromosome | Gene name | SNP | Genotype | Cases | Controls | OR (95% CI) | P-value |
|---|---|---|---|---|---|---|---|
| 7 | HUS1 | rs2708896 | GG | 53 | 108 | 1 | |
| TG | 81 | 199 | 0.78(0.51–1.21) | 0.269937173 | |||
| TT | 29 | 120 | 0.46(0.27–0.79) | 0.004725606 | |||
| P for trend | 0.005150922 | ||||||
| TG & TT | 110 | 319 | 0.66(0.44–0.99) | 0.047220849 | |||
| 7 | HUS1 | rs10951937 | TT | 68 | 142 | 1 | |
| TG | 78 | 185 | 0.86(0.57–1.28) | 0.447883484 | |||
| GG | 17 | 100 | 0.35(0.19–0.65) | 0.000708759 | |||
| P for trend | 0.001602607 | ||||||
| GG & TG | 95 | 285 | 0.68(0.47–1.00) | 0.048742011 | |||
| 10 | MGMT | rs12769288 | CC | 141 | 317 | 1 | |
| TC | 20 | 101 | 0.43(0.25–0.73) | 0.001710087 | |||
| TT | 2 | 9 | 0.47(0.10–2.26) | 0.347352446 | |||
| P for trend | 0.002130931 | ||||||
| TC & TT | 22 | 110 | 0.43(0.26–0.72) | 0.001229464 | |||