Table 4.

Statistically significant effect modification of genotypes between diagnostic radiation exposure and risk of thyroid cancer (n=905).

Chromosome	Gene name	Genotype	Non-exposed			Exposed
			Cases	Controls	OR* (95% CI)	Cases	Controls	OR* (95% CI)
3	TOPBP1_06	rs17301766
		CC	21	40	1.00	269	260	1.96 (1.06–3.66)
		TC or TT	15	12	1.00	134	152	0.81 (0.33–1.98)
		P for interaction						0.028
3	TOPBP1_09	rs11706586
		CC	20	40	1.00	267	262	2.06 (1.10–3.86)
		TC or TT	15	12	1.00	135	151	0.85 (0.35–2.08)
		P for interaction						0.025
3	TOPBP1_10	rs7349558
		AA	22	40	1.00	270	257	1.94 (1.05–3.59)
		AC or CC	14	12	1.00	133	156	0.79 (0.32–1.95)
		P for interaction						0.039
7	RPA3_01	rs4720751
		TT	20	24	1.00	175	217	0.85 (0.43–1.71)
		TC or CC	15	28	1.00	227	196	2.91 (1.39–6.09)
		P for interaction						0.034
7	RPA3_02	rs17136898
		AA	22	41	1.00	301	292	2.11 (1.15–3.88)
		AG or GG	13	11	1.00	101	121	0.78 (0.29–2.07)
		P for interaction						0.050
7	XRCC2_01	rs10234749
		CC	19	36	1.00	279	251	2.51 (1.32–4.75)
		AC or AA	16	16	1.00	122	162	0.59 (0.25–1.44)
		P for interaction						0.025
10	MGMT_02	rs1762444
		GG	8	25	1.00	158	161	3.36 (1.37–8.27)
		AG or AA	27	27	1.00	244	252	0.98 (0.52–1.85)
		P for interaction						0.024
10	MGMT_32	rs12219606
		CC	8	21	1.00	139	143	2.55 (0.98–6.65)
		AC or AA	27	31	1.00	265	270	1.19 (0.65–2.16)
		P for interaction						0.049
10	MGMT_36	rs4750763
		AA	7	26	1.00	165	171	3.79 (1.44–9.98)
		AC or CC	28	26	1.00	237	242	0.99 (0.54–1.85)
		P for interaction						0.015
11	ALKBH3_03	rs11037690
		GG	14	32	1.00	203	193	2.43 (1.15–5.14)
		AG or AA	21	20	1.00	198	220	0.99 (0.48–2.02)
		P for interaction						0.029
11	ALKBH3_14	rs10768994
		TT	8	26	1.00	137	131	2.88 (1.13–7.29)
		TC or CC	28	26	1.00	267	282	0.99 (0.53–1.84)
		P for interaction						0.0086
11	ALKBH3_15	rs10768995
		GG	21	19	1.00	146	158	0.97 (0.45–2.09)
		GC or CC	14	33	1.00	256	255	2.37 (1.16–4.86)
		P for interaction						0.012
11	ALKBH3_19	rs868784
		CC	11	29	1.00	169	155	2.66 (1.16–6.12)
		TC or TT	24	23	1.00	233	258	1.06 (0.54–2.05)
		P for interaction						0.018
11	ALKBH3_20	rs3893853
		CC	20	38	1.00	275	247	2.01 (1.06–3.82)
		TC or TT	16	14	1.00	128	166	0.85 (0.36–1.98)
		P for interaction						0.014
11	ALKBH3_21	rs4755217
		TT	8	26	1.00	137	133	2.86 (1.13–7.24)
		TC or CC	27	25	1.00	259	275	1.03 (0.55–1.95)
		P for interaction						0.014
11	ALKBH3_22	rs1973717
		CC	20	20	1.00	155	165	1.10 (0.52–2.34)
		TC or TT	15	32	1.00	245	247	2.09 (1.03–4.26)
		P for interaction						0.045
13	PARP4_04	rs4770687
		GG	14	13	1.00	99	121	0.62 (0.23–1.65)
		AG or AA	22	39	1.00	303	291	2.28 (1.24–4.19)
		P for interaction						0.043
19	LIG1_01	rs251693
		TT	16	18	1.00	112	138	0.71 (0.32–1.61)
		TC or CC	19	34	1.00	291	275	2.51 (1.30–4.83)
		P for interaction						0.024
19	LIG1_02	rs2288878
		GG	16	18	1.00	108	137	0.72 (0.32–1.61)
		AG or AA	20	34	1.00	294	276	2.36 (1.23–4.50)
		P for interaction						0.024
19	LIG1_03	rs274897
		CC	16	18	1.00	109	138	0.69 (0.30–1.55)
		GC or GG	19	34	1.00	293	274	2.55 (1.32–4.91)
		P for interaction						0.020
19	LIG1_04	rs2386523
		CC	14	15	1.00	86	103	0.73 (0.30–1.80)
		TC or TT	21	37	1.00	317	309	2.34 (1.25–4.38)
		P for interaction						0.025
19	LIG1_05	rs2163619
		GG	13	13	1.00	73	95	0.57 (0.22–1.50)
		AG or AA	22	39	1.00	330	316	2.40 (1.30–4.42)
		P for interaction						0.0060
19	LIG1_07	rs274873
		AA	14	16	1.00	95	111	0.59 (0.24–1.46)
		AG or GG	22	36	1.00	308	302	2.24 (1.21–4.15)
		P for interaction						0.035
19	LIG1_10	rs10421339
		GG	15	15	1.00	94	113	0.45 (0.18–1.16)
		GC or CC	20	37	1.00	308	300	2.50 (1.34–4.69)
		P for interaction						0.0081
X	UBE2A_01	rs5910616
		GG	33	43	1.00	309	328	1.28 (0.75–2.19)
		AG or GG	2	9	1.00	91	85	6.82 (1.08–43.08)
		P for interaction						0.043

^*Adjusted for age (continuous), gender, race, and BMI.

OR: Odds Ratio; CI: Confidence Interval