Table 5.

Statistically significant effect modification of genotypes between diagnostic radiation exposure and risk of papillary thyroid cancer (n=838).

Chromosome	Gene name	Genotype	Non-exposed			Exposed
			Cases	Controls	OR* (95% CI)	Cases	Controls	OR* (95% CI)
3	TOPBP1_06	rs17301766
		CC	21	40	1.00	221	260	1.62 (0.86–3.06)
		TC or TT	14	12	1.00	116	152	0.79 (0.32–1.96)
		P for interaction						0.044
3	TOPBP1_09	rs11706586
		CC	20	40	1.00	221	262	1.73 (0.91–3.27)
		TC or TT	14	12	1.00	115	151	0.81 (0.33–2.01)
		P for interaction						0.035
7	RPA3_01	rs4720751
		TT	19	24	1.00	141	217	0.69 (0.33–1.41)
		TC or CC	15	28	1.00	196	196	2.73 (1.29–5.75)
		P for interaction						0.024
7	HUS1_03	rs3176595
		GG	31	36	1.00	261	328	1.03 (0.59–1.82)
		AG or AA	4	16	1.00	74	84	4.20 (1.09–16.23)
		P for interaction						0.033
7	XRCC2_01	rs10234749
		CC	18	36	1.00	231	251	2.24 (1.16–4.32)
		AC or AA	16	16	1.00	104	162	0.50 (0.20–1.24)
		P for interaction						0.026
10	MGMT_02	rs1762444
		GG	8	25	1.00	131	161	2.86 (1.15–7.11)
		AG or AA	26	27	1.00	205	252	0.84 (0.44–1.62)
		P for interaction						0.025
10	MGMT_36	rs4750763
		AA	7	26	1.00	137	171	3.49 (1.30–9.39)
		AC or CC	27	26	1.00	199	242	0.85 (0.45–1.59)
		P for interaction						0.016
11	ALKBH3_03	rs11037690
		GG	13	32	1.00	171	193	2.16 (0.99–4.72)
		AG or AA	21	20	1.00	164	220	0.88 (0.43–1.81)
		P for interaction						0.026
11	ALKBH3_14	rs10768994
		TT	8	26	1.00	115	131	2.40 (0.93–6.17)
		TC or CC	27	26	1.00	223	282	0.87 (0.46–1.63)
		P for interaction						0.010
11	ALKBH3_15	rs10768995
		GG	21	19	1.00	124	158	0.83 (0.38–1.80)
		GC or CC	13	33	1.00	212	255	2.21 (1.05–4.64)
		P for interaction						0.011
11	ALKBH3_19	rs868784
		CC	10	29	1.00	144	155	2.40 (1.01–5.72)
		TC or TT	24	23	1.00	193	258	0.92 (0.47–1.80)
		P for interaction						0.014
11	ALKBH3_20	rs3893853
		CC	19	38	1.00	231	247	1.72 (0.89–3.34)
		TC or TT	16	14	1.00	106	166	0.74 (0.31–1.74)
		P for interaction						0.013
11	ALKBH3_21	rs4755217
		TT	8	26	1.00	116	133	2.47 (0.96–6.32)
		TC or CC	26	25	1.00	214	275	0.90 (0.47–1.72)
		P for interaction						0.015
11	ALKBH3_22	rs1973717
		CC	20	20	1.00	133	165	0.95 (0.44–2.04)
		TC or TT	14	32	1.00	201	247	1.89 (0.91–3.96)
		P for interaction						0.048
13	PARP4_04	rs4770687
		GG	13	13	1.00	80	121	0.56 (0.20–1.55)
		AG or AA	22	39	1.00	256	291	1.92 (1.04–3.54)
		P for interaction						0.042
19	LIG1_01	rs251693
		TT	16	18	1.00	93	138	0.55 (0.24–1.28)
		TC or CC	18	34	1.00	244	275	2.33 (1.19–4.56)
		P for interaction						0.019
19	LIG1_02	rs2288878
		GG	16	18	1.00	90	137	0.55 (0.24–1.28)
		AG or AA	19	34	1.00	246	276	2.20 (1.13–4.27)
		P for interaction						0.020
19	LIG1_03	rs274897
		CC	16	18	1.00	90	138	0.52 (0.22–1.21)
		GC or GG	18	34	1.00	246	274	2.38 (1.22–4.67)
		P for interaction						0.015
19	LIG1_04	rs2386523
		CC	14	15	1.00	72	103	0.56 (0.22–1.43)
		TC or TT	20	37	1.00	265	309	2.16 (1.14–4.10)
		P for interaction						0.020
19	LIG1_05	rs2163619
		GG	13	13	1.00	61	95	0.39 (0.14–1.12)
		AG or AA	21	39	1.00	276	316	2.19 (1.17–4.09)
		P for interaction						0.0044
19	LIG1_07	rs274873
		AA	14	16	1.00	79	111	0.43 (0.16–1.11)
		AG or GG	21	36	1.00	258	302	2.07 (1.10–3.90)
		P for interaction						0.026
19	LIG1_10	rs10421339
		GG	15	15	1.00	79	113	0.34 (0.12–0.91)
		GC or CC	19	37	1.00	257	300	2.29 (1.20–4.36)
		P for interaction						0.0066
X	UBE2A_01	rs5910616
		GG	32	43	1.00	256	328	1.11 (0.64–1.92)
		AG or AA	2	9	1.00	80	85	6.35 (1.00–40.40)
		P for interaction						0.034

^*Adjusted for age (continuous), gender, race, and BMI.

OR: Odds Ratio; CI: Confidence Interval