Table 6.

Statistically significant effect modification of genotypes between diagnostic radiation exposure and risk of thyroid microcarcinoma (n=672).

Chromosome	Gene name	Genotype	Non-exposed			Exposed
			Cases	Controls	OR* (95% CI)	Cases	Controls	OR* (95% CI)
7	XRCC2_01	rs10234749
		CC	3	36	1.00	135	251	7.82 (2.20–27.78)
		AC or AA	6	16	1.00	60	162	0.65 (0.20–2.11)
		P for interaction						0.0041
10	MGMT_33	rs10829618
		GG	3	41	1.00	122	264	7.16 (2.02–25.39)
		GC or CC	6	11	1.00	75	149	0.99 (0.32–3.12)
		P for interaction						0.036
10	MGMT_39	rs4751112
		AA	3	39	1.00	118	256	6.78 (1.89–24.30)
		AG or GG	7	13	1.00	79	157	1.01 (0.34–2.99)
		P for interaction						0.045
11	ALKBH3_01	rs12804822
		AA	2	33	1.00	109	232	8.92 (1.96–40.55)
		AC or CC	7	19	1.00	88	181	1.23 (0.44–3.46)
		P for interaction						0.022
11	ALKBH3_07	rs3740983
		TT	2	32	1.00	104	224	9.52 (2.07–43.81)
		TG or GG	7	20	1.00	93	189	1.29 (0.47–3.53)
		P for interaction						0.030
11	ALKBH3_08	rs7482199
		TT	2	34	1.00	103	231	8.97 (1.97–40.92)
		TC or CC	8	18	1.00	94	182	1.15 (0.43–3.07)
		P for interaction						0.018
11	ALKBH3_11	rs11037726
		AA	2	34	1.00	106	233	9.01 (1.97–41.15)
		TA or TT	8	18	1.00	91	179	1.17 (0.44–3.15)
		P for interaction						0.017
13	PARP4_04	rs4770687
		GG	6	13	1.00	48	121	0.62 (0.18–2.16)
		AG or AA	4	39	1.00	148	291	5.73 (1.89–17.40)
		P for interaction						0.020
13	ERCC5_07	rs4150355
		GG	7	22	1.00	77	173	1.35 (0.49–3.69)
		AG or AA	2	30	1.00	120	240	8.01 (1.72–37.23)
		P for interaction						0.033
13	ERCC5_11	rs17655
		GG	9	29	1.00	102	244	0.95 (0.39–2.35)
		CG or CC	1	23	1.00	95	169	21.97 (2.74–176.47)
		P for interaction						0.030
13	ERCC5_13	rs9586002
		GG	2	31	1.00	120	243	8.88 (1.96–40.16)
		TG or TT	7	21	1.00	77	170	1.11 (0.40–3.10)
		P for interaction						0.033
13	ERCC5_14	rs1886087
		AA	6	16	1.00	52	111	1.47 (0.47–4.62)
		TA or TT	3	36	1.00	145	302	5.77 (1.62–20.54)
		P for interaction						0.036

^*Adjusted for age (continuous), gender, race, and BMI.

OR: Odds Ratio; CI: Confidence Interval