Table 1.

Inhibitors of the Angiogenesis Pathway

Inhibitor	Cell Type	Process Inhibited	Pathway	Reference
Stigmatellin	WT cybrids; in vitro	Inhibits HIF-1α stabilization and accumulation	Binding to Qo site inhibits mROS production	[17]
Terpestacin in vivo	Murine FM3A breast cancer cells; in vivo	Inhibits tumor angiogenesis	Inhibition of HIF-1α Mediated VEGF expression	[27]
Terpestacin in vitro	Human HT1080 fibrosarcoma cells, HUVECs; in vitro	Inhibits VEGF production; inhibits tube formation and angiogenesis by HUVECs	Decreases mROS levels by inhibiting UQCRB which inhibits HIF-1α stabilization and accumulation, inhibiting VEGF production	[27]
Uqcrb-MO	Zebrafish embryos	Inhibits VEGF production	Gene knockdown of uqcrb gene leads to decreased expression of vegfa gene	[28]
siUQCRB	HUVECs; in vitro	Inhibits endothelial cell invasiveness through inhibition of ERK and Akt pathways	Gene knockdown of uqcrb leads to decreased mROS levels, decreased activation of VEGFR2	[29]
Rotenone and thenoyltrifluoroacetone (TTFA)	Cardiomyocytes; in vitro	Inhibits mROS production	Inhibits formation of ubiquinol by preventing transfer of electrons from Complex I and Complex II	[40]
Matairesinol	HUVECs; in vitro and in vivo	Inhibits HUVEC tube formation	Inhibits mROS production which decreases HIF-1α stabilization and VEGF production	[74]
GPX1 and catalase	A549 adenocarcinomic human alveolar basal epithelial cells; in vitro	Inhibits HIF-1α stabilization and survival	Breaks down hydrogen peroxide to water which prevents breakdown of prolyl hydroxylase	[76]