Figure 8.

A) Activatable aptamer probe for in vivo cancer imaging based on cell membrane protein-triggered conformation alteration. Reproduced with permission.^[109] Copyright 2011, PNAS. B) Split aptamer-based activatable theranostic probe (SATP) for in vivo cancer imaging. Reproduced with permission.^[111] Copyright 2016, American Chemical Society. C) Aptamer-embedded DNA tetrahedral nanostructures for intracellular logic sensors. Reproduced with permission.^[116] Copyright 2012, Wiley-VCH. D) Aptamer-embedded RNA tetrahedral nanostructures for cancer targeting. Reproduced with permission.^[119] Copyright 2016, Wiley-VCH. E) Illustration of the construction of thrombin-loaded nanorobot by aptamer-embedded DNA origami as a cancer therapeutic. Reproduced with permission.^[129] Copyright 2018, Nature Publishing Group. F) Aptamer-based DNA nanoprobes for in vivo photoacoustic imaging. Reproduced with permission.^[135] Copyright 2017, American Chemical Society.