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. Author manuscript; available in PMC: 2020 Jun 1.
Published in final edited form as: Pharmacogenomics J. 2018 Sep 20;19(3):295–304. doi: 10.1038/s41397-018-0049-x

Table 3.

RHTN SNPs: discovery in INVEST with replication in SPS3

SNP Ch Position Nearest gene A1 Study White-Hispanic OR (95% CI) White-Hispanic meta-analysis p INVEST–SPS3 meta-analysis OR (95% CI) INVEST–SPS3 meta-analysis p Heterogeneity p
rs11749255 5 174642665 MSX2 A INVEST 1.5 (1.2, 1.8) 7.3 × 10−5 1.60 (1.3, 1.9) 3.8 × 10−8 0.14
SPS3 2.0 (1.4, 2.8) 4.4 × 10−5
rs6487504 12 25654374 IFLTD1 A INVEST 1.9 (1.4, 2.5) 1.1 × 10−5 1.81 (1.4, 2.3) 1.6 × 10−7 0.92
SPS3 1.7 (1.2, 2.5) 4.0 × 10−3
rs324498 9 9059545 PTPRD G INVEST 1.62 (1.3, 2.0) 3.4 × 10−5 1.62 (1.3, 2.0) 1.3 × 10−6 1
SPS3 1.63 (1.1, 2.4) 0.01

A1 coded allele, OR odds ratio, Heterogeneity p INVEST-SPS meta-analysis heterogeneity p-value