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. 2019 Feb 26;16:194–205. doi: 10.1016/j.omtn.2019.02.013

Figure 5.

Figure 5

siRNA Activity Is Affected by siRNA PEGylation and Does Not Require Aerosolization

(A) Plot represents Ctnnb1 mRNA in isolated cell subsets relative to Ppib control 72 h after 15 mg/kg siRNA intratracheal dosing. (B) siRNA content in isolated cell subsets determined by stem-loop PCR. (C) Ctnnb1 mRNA levels were determined 72 h after dosing 50 mg/kg siRNA intratracheally with a microsprayer syringe or by direct instillation. Lines indicate means ± SE. **p < 0.005, ***p < 0.001, ****p < 0.0001 versus PBS-treated cell subset; #p < 0.05, ###p < 0.001, ####p < 0.0001 versus si-Ctnnb1 VP-dosed subsets; n.s., not significant.