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. 2019 Mar 14;11:4. doi: 10.3389/fnsyn.2019.00004

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Copyright © 2019 Park, Kang, Sanderson, Bortolotto, Georgiou, Zhuo, Kaang and Collingridge.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The role of protein synthesis in heterosynaptic facilitation of LTP. (A) Anisomycin (30 μM; Ani) applied during the sTBS prevents heterosynaptic facilitation of LTP (n = 8). (B) Superimposition of the LTP induced by wTBS for anisomycin-treated (blue; from A) and untreated controls (black; replotted from Figure 3E). (C) Anisomycin applied during the wTBS reduces heterosynaptic facilitation of LTP (n = 9). (D) Superimposition of the LTP induced by wTBS for anisomycin-treated (green; from C) and untreated controls (black; replotted from Figure 3E). (E) Quantification (2 h post sTBS) of the effects of anisomycin on the LTP induced by sTBS showing the timing-dependent inhibition of LTP2. (F) Quantification (90 min post wTBS) of the effects of anisomycin on the LTP induced by wTBS. ^∗p < 0.05; ^∗∗p < 0.01; comparisons vs. sTBS.