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. 2019 Mar 14;11:4. doi: 10.3389/fnsyn.2019.00004

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Copyright © 2019 Park, Kang, Sanderson, Bortolotto, Georgiou, Zhuo, Kaang and Collingridge.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Evidence that synaptic tagging and capture involves CP-AMPARs. (A) IEM-1460 (30 μM; IEM) applied during the sTBS prevents synaptic tagging (n = 8). (B) Superimposition of the LTP induced by wTBS to illustrate the magnitude of the effect of IEM treatment (purple; from A) compared to untreated controls (black; replotted from Figure 3E). (C) IEM applied during the wTBS reduces synaptic tagging (n = 10). (D) Superimposition of the LTP induced by wTBS to illustrate the magnitude of the effect of IEM treatment (orange; from C) compared to untreated conditions (black; replotted from Figure 3E). (E) Quantification (2 h post sTBS) of the effects of IEM on the LTP induced by sTBS, showing its timing-dependent inhibition of LTP2. (F) Quantification (90 min post wTBS) of the effects of IEM on the LTP induced by wTBS. ^∗p < 0.05; ^∗∗p < 0.01; ^∗∗∗p < 0.001; comparisons vs. sTBS.