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. 2019 Mar 14;10:436. doi: 10.3389/fimmu.2019.00436

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Copyright © 2019 Pandit and De Boer.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Variation of the marker distribution as a function of family size in the basic model. The fraction of CD8⁺ T cells that are positive for CD62L (A), CD27 (B), and KLRG1 (C) markers is shown for each CD8⁺ T cell family. Each bullet represents one naïve CD8⁺ T cell family. These results are based on simulating the clonal expansion of a 1,000 naïve CD8⁺ T cells.