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. 2019 Mar 14;10:477. doi: 10.3389/fmicb.2019.00477

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Copyright © 2019 Gao, Li, Wan, Hu, Liu, Yang, Gong, Zeng, Wei, Yang, Zeng, He, Huang and Cao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Protective effect of HM0539 on DSS-induced colitis. C57BL/6 mice were randomly divided into control group (CON), DSS-colitis group (DSS) and HM0539-treated DSS-colitis group (HM0539 + DSS). Mice were gavage fed with pectin/zein control or pectin/zein beads containing HM0539 from days 1 to 9. DSS colitis was induced by adding 3% DSS in the drinking water from days 3 to 9. All mice were sacrificed at day 12, the colitis severity and intestinal dysfunction were evaluated. (A) Body weight of mice from 1 to 7 days after DSS treatment. (B,C) Colon length of mice at day 12. Immunohistochemical staining and semiquantitative analysis of MUC2 (D, upper panel, E) and ZO-1 (D, middle panel, F) of the colon section. (D, lower panel) HE staining of colon section. Data are given as means ± SEM; ^∗∗P < 0.01, ^∗∗∗P < 0.001.