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Schematic representation of overall conclusions. Tau normally associates with ribosomes and facilitates translation between global transcripts and 5′TOP mRNA sequences. In disease conditions, pathological tau species reduce the efficiency of translation and prevent rpS6 phosphorylation at S240/S244. As rpS6 activity decreases, translation of 5′TOP mRNAs coding for ribosomal and translational machinery is reduced, impairing global translation
