Table 1.

Birth defects by the Medical Dictionary for Regulatory Activities (MedDRA)

MedDRA sub-class of congenital, familial, and genetic disorders	Frequency
Musculoskeletal and connective tissue disorders congenital	63
Cardiac and vascular disorders congenital	46
Gastrointestinal tract disorders congenital	45
Chromosomal abnormalities and abnormal gene carriers	21
Neurological disorders congenital	13
Renal and urinary tract disorders congenital	5
Eye disorders congenital	3
Respiratory disorders congenital	3
Skin and subcutaneous tissue disorders congenital	2
Blood and lymphatic system disorders congenital	2
Hepatobiliary disorders congenital	1
Reproductive tract and breast disorders congenital	1
Ear and labyrinth disorders congenital	1

The sum of the frequencies is slightly greater than the number of cases; this is because, in some of the individual cases, the child had multiple birth defects and the defects belonged to different sub-classes