Table 4.
Percentage of instances of intake of ‘probably safe’, ‘potentially risky’, and ‘unclassified’ medications
| Instances in cases, % (n/N) | Instances in controls, % (n/N) | p valuea | |
|---|---|---|---|
| First trimester, N | 27 | 8 | |
| ‘Probably safe’ medication | 67 (18/27) | 63 (5/8) | 0.70 |
| ‘Potentially risky’ medication | 22 (6/27) | 13 (1/8) | |
| ‘Unclassified’ medication | 11 (3/27) | 25 (2/8) | |
| Second trimester, N | 39 | 14 | |
| ‘Probably safe’ medication | 61 (24/39) | 64 (9/14) | 0.75 |
| ‘Potentially risky’ medication | 15 (6/39) | 21 (3/14) | |
| ‘Unclassified’ medication | 23 (9/39) | 14 (2/14) | |
| Third trimester, N | 60 | 26 | |
| ‘Probably safe’ medication | 73 (44/60) | 77 (20/26) | 0.93 |
| ‘Potentially risky’ medication | 15 (9/60) | 15 (4/26) | |
| ‘Unclassified’ medication | 12 (7/60) | 8 (2/26) | |
| Total pregnancy, N | 126 | 48 | |
| ‘Probably safe’ medication | 68 (86/126) | 71 (34/48) | 0.97 |
| ‘Potentially risky’ medication | 17 (21/126) | 17 (8/48) | |
| ‘Unclassified’ medication | 15 (19/126) | 13 (6/48) |
The ‘probably safe’ category consisted of A, B1, and B2 classifications and the ‘potentially risky’ category consisted of B3, C, D, and X as per the Australian categorization system (https://www.tga.gov.au/prescribing-medicines-pregnancy-database)
aFisher’s exact t test