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. 2019 Jan 17;10(2):43. doi: 10.1038/s41419-018-1282-6

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — HCC samples were divided into four groups of Twist1/TP (−/−), Twist1/TP (−/+), Twist1/TP (+/−), and Twist1/TP (+/+) according to the Twist1/TP expression levels. a Correlation between Twist1/TP expression and HCC characteristics, including metastasis, clinical stage, pathology grade, carcinoembryonic antigen (CEA) level, alpha-fetoprotein (AFP) level, and gender. b Overall survival analysis of Twist1/TP on patients with HCC. c Correlation analysis between vasculogenic mimicry (VM) formation and Twist1 and TP expression in 306 cases of HCC. The VM channel was PAS positive, but it did not express CD31 (red arrow). Endothelial vessels were PAS- and CD31-positive (yellow arrow). d Analysis of the HCC specimens by IHC. VE–Cad, vascular endothelial growth factor receptor 1 (VEGFR1), and VEGFR2 were minimally expressed in the Twist1- and TP-negative expression groups. When Twist1 and TP were individually or both positively expressed, the expression levels of the three marker proteins increased. e Statistical analysis of protein expression in 306 HCC specimens among the four groups (mean ± SD; *P < 0.05; **P < 0.01)