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. 2019 Mar 20;9:4925. doi: 10.1038/s41598-019-41346-3

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Effects of WTCAP1 and the phosphor mutants in rescuing the reduced motility and invasion in the CAP1-knockdown PANC-1 cells. (A) WTCAP1 and the AA mutant effectively rescued the reduced motility in the CAP1-knockdown PANC-1 cells in Transwell migration assays, while the DD mutant failed in doing so. The experiments, data collection and analyses were conducted similarly to that described in Fig. 2. The error bars represent S.E.M., and “*” indicates P < 0.05 as compared to the control cells harboring an empty vector (Vec-R). (B) WTCAP1 and the AA mutant effectively rescued the reduced Matrigel invasion of the CAP1-knockdown PANC-1 cells, while the DD mutant also failed to do so. The experiments, data collection and analyses were conducted similarly to that described in Fig. 2. The error bars represent S.E.M., and “*” indicates P < 0.05 as compared to the control cells. (C) Re-expression of WTCAP1 also rescued the up-regulated E-Cadherin in the CAP1-knockdown PANC-1 cells.