Table 1.

Allele and genotype distributions of the VDR rs2228570 variant (FokI) in sporadic essential tremor patients and controls, and in male and female sporadic essential tremor patients and controls.

Gene	Cases	Controls	χ 2	P value	OR (95%CI)
VDR rs2228570	239 (100.0%)	239 (100.0%)	5.206	0.074
CC	129 (54.0%)	114 (47.7%)	1.883	0.170	1.286 (0.898–1.842)
CT	99 (41.4%)	102 (42.7%)	0.077	0.781	0.950 (0.661–1.366)
TT	11 (4.6%)	23 (9.6%)	4.560	0.033	0.453 (0.216–0.952)
CC + CT dominant	228 (95.4%)	216 (90.4%)	4.560	0.033	2.207 (1.051–4.636)
CT + TT recessive	110 (46%)	125 (52.3%)	1.883	0.170	0.778 (0.543–1.114)
Allele frequency
C allele	357 (75%)	330 (69%)	4.560	0.033	2.207 (1.051–4.636)
T allele	121 (25%)	148 (31%)	1.883	0.170	0.778 (0.543–1.114)
HWE (exact)	0.17	1.0
SP	0.31	0.31

Gene	Male cases	Male controls	χ 2	P value	OR (95% CI)
VDR rs2228570	129 (100.0%)	129 (100.0%)	7.962	0.019
CC	75 (58.1%)	57 (44.2%)	5.026	0.025	1.754 (1.072–2.872)
CT	50 (38.8%)	59 (45.7%)	1.287	0.257	0.751 (0.458–1.232)
TT	4 (3.1%)	13 (10.1%)	5.101	0.024	0.286 (0.091–0.901)
Allele frequency
C allele	200 (78%)	173 (67%)	5.101	0.024	3.502 (1.110–11.047)
T allele	58 (22%)	85 (33%)	5.026	0.025	0.570 (0.348–0.933)
HWE (exact)	0.31	0.84
SP	0.51	0.51

Gene	Female cases	Female controls	χ 2	P value	OR (95%CI)
VDR rs2228570	110 (100.0%)	110 (100.0%)	1.002	0.606
CC	54 (49.1%)	57 (51.8%)	0.164	0.686	0.897 (0.528–1.521)
CT	49 (44.5%)	43 (39.1%)	0.673	0.412	1.252 (0.732–2.141)
TT	7 (6.4%)	10 (9.1%)	0.574	0.449	0.680 (0.249–1.855)
Allele frequency
C allele	157 (71%)	157 (71%)	0.574	0.449	1.471 (0.539–4.017)
T allele	63 (29%)	63 (29%)	0.164	0.686	1.115 (0.657–1.893)
HWE (exact)	0.48	0.64

SP Statistical power, HWE Hardy–Weinberg equilibrium, VDR vitamin D receptor.