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. 2019 Jan 15;10(2):39. doi: 10.1038/s41419-018-1135-3

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — Columns represent the mean + SD. *P < 0.05, **P < 0.01, independent samples t-test. W WY14643, P pioglitazone, T TNFα. a Associations between the levels of Fatp1 expression and total FFAs. n = 3 per group. b Associations between the levels of Fatp1 expression and TGs. n = 3 per group. c Associations between total FFA and TG content. n = 3 per group. d Selective PPARα and PPARγ agonists abolished the oleate-induced suppression of PPAR signaling. n = 4 per group. e Selective PPARα and PPARγ agonists attenuated oleate-induced FFA and TG accumulation. n = 3 per group. f Selective inhibition of FATP1 by TNFα. n = 4 per group. g Selective inhibition of FATP1 attenuated oleate-induced FFA and TG accumulation. n = 3 per group. h Molecular mechanisms by which PPARα and PPARγ attenuate oleate-induced FFA and TG accumulation in macrophages. Solid arrows on the right of terms: upward/downward arrows denote increases/decreases in response to oleate. Dotted arrows on the left of terms: upward/downward arrows denote increases/decreases in response to PPARα and PPARγ agonists. i Selective PPARα and PPARγ agonists abolished oleate-induced neutral lipid accumulation. n = 6–10 per group. j Associations between changes in FFAs and changes in neutral lipids in macrophages treated with oleate, oleate+W and oleate+P (n = 3 per group). k Associations between changes in TGs and changes in neutral lipids in macrophages treated with oleate, oleate+W and oleate+P (n = 3 per group)