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WT and C116S PHGDH inhibition (IC50) of DSF.
| PHGDH | PHGDH inhibition (IC50, µM)a |
|---|---|
| Wild Type | 0.59 [0.37–0.95] |
| C116S mutant | 10.23 [6.68–15.65] |
aAll experiments to determine IC50 values were performed in triplicates at each compound dilution, and all IC50 values were averaged when determined in two or more independent experiments. Under bracket: 95% confidence interval.
