Fig. 6. On-network representation of significant metabolic changes.

a Comparison of nMSCs vs. iMSC ARG, showed that iMSC ARG had a lower glycolytic and glutaminolytic activity, lower levels of TCA and urea cycle metabolites and decreased amino-acid pools compared with nMSCs. b IFNG stimulation diminished the differences in metabolic phenotype between nMSC (T) and iMSC ARG (T) seen in a. The only difference are increased levels of glutamine and serine in iMSC ARG (T). c INFG treatment did not increase metabolic activity of iMSC TEX (T). Glutaminolysis and the levels of biosynthetic precursors (amino acids and lipid precursors such as myoinositol) was significantly lower in comparison with both nMSC (T) and iMSC ARG (T). (T), IFNG-treated cells