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. 2019 Mar 18;9:4758. doi: 10.1038/s41598-019-41188-z

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Heat capacity profiles of the three investigated cell lines. Heat capacity profiles of HT29 (colon cancer cell line; left), MDA-MB231 (breast cancer cell line; middle), and HDF-n (normal dermal fibroblast cell line; right). Solid lines represent the first scan over the full temperature range (0–90 °C). Dashed lines represent the second calorimetric scan over the full temperature range. The protein peaks have disappeared (because the proteins have denaturated in the first scan over the full range of temperatures) while the lipid peaks remain. The amplitude of the lipid peaks can change between scans due to subtraction of base line but the position of the peak (temperature) is more constant between scans. The vertical line represents the physiological temperature. Bottom panel: enlargement of the top panel from 0–40 °C, where approximate transition temperatures are indicated.