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. 2019 Mar 14;10:486. doi: 10.3389/fmicb.2019.00486

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Copyright © 2019 Pinto, Neves, Souza, Oliveira, Costa, Castro, Mendonça-Souza, Peralta and Teixeira.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Distribution over time of pneumococci with reduced susceptibility to penicillin (PRSP), penicillin-resistant pneumococci (PRP), and high-level penicillin resistant pneumococci (HLPRP). (A) Distribution among 355 S. pneumoniae isolates recovered from asymptomatic carriers. (B) Distribution among 428 S. pneumoniae isolates recovered from patients with IPD. Isolates showing penicillin MICs ≥ 0.12 < 2 μg/ml were classified as PRSP, those with MICs ≥ 2 < 4 μg/ml were classified as PRP and those with MIC ≥ 4 μg/ml were classified as HLPRP.