Table 3.
Distribution of Streptococcus pneumoniae isolates non-susceptible to penicillin (PNSP) among nine capsular types mostly associated with penicillin resistance, according to the clinical source.
| Capsular type (n) | % PNSP (n) | Carriagea |
IPDa |
||||
|---|---|---|---|---|---|---|---|
| % PNSP | MIC50b | MIC90b | % PNSP | MIC50b | MIC90b | ||
| 6A (26) | 26.9 (7) | 36.8 | 0.06 | 2 | 0 | 0.01 | 0.03 |
| 6B (63) | 38.1 (24) | 31.4 | 0.06 | 0.25 | 46.4 | 0.06 | 0.32 |
| 6C (40) | 40 (16) | 50 | 0.06 | 0.75 | 0 | 0.01 | 0.06 |
| 14 (86) | 52.3 (45) | 82.7 | 2 | 4 | 36.8 | 0.06 | 1.5 |
| 19A (22) | 36.4 (8) | 45.4 | 0.06 | 8 | 27.3 | 0.05 | 8 |
| 19F (62) | 17.7 (11) | 17.5 | 0.06 | 0.12 | 18.2 | 0.06 | 0.25 |
| 23F (51) | 49 (25) | 61.3 | 0.12 | 0.25 | 30 | 0.06 | 0.25 |
| 35B (7) | 57.1 (4) | 66.7 | 1 | 4 | 0 | 0.01 | 0.01 |
| NT (13) | 61.5 (8) | 61.5 | 0.19 | 4 | 0 | NA | NA |
aCarriage isolates included strains recovered from nasopharynx or oropharynx specimens while IPD (invasive pneumococcal disease) isolates included those recovered from blood or cerebrospinal fluid.
bμg/ml. NA, not applicable since no strain belonging to such serotype was detected. Strains showing penicillin MICs ≥ 0.12 μg/ml were classified as penicillin non-susceptible pneumococci (PNSP). Serotypes comprised by PCV10 are highlighted in green, those included only in PCV13 are highlighted in yellow, those not included in any PCV currently available are not colored.