Table 4.
Comparison of clinical and demographic features of sepsis-induced brain dysfunction patients with and without cognitive impairment
| Parameters | MMSE <24 (n=7) | MMSE 24–30 (n=14) | p value* |
|---|---|---|---|
| Age | 57.3±3.1 | 53.2±3.0 | 0.179 |
| Gender (men/women) | 4/3 | 8/6 | >0.999 |
| Duration of education (years) | 7.1±1.1 | 8.7±1.0 | 0.148 |
| Time of cognitive assessment (days after hospitalization) | 6.7±2.5 | 7.9±1.8 | 0.349 |
| ACE-R | 57.9±5.2 | 76.1±3.2 | 0.006 |
| Orientation-attention score | 12.1±0.7 | 17.1±0.3 | <0.001 |
| Memory score | 13.6±1.5 | 16.7±0.9 | 0.048 |
| Verbal fluency score | 4.9±0.8 | 7.6±0.7 | 0.012 |
| Language score | 15.6±2.0 | 20.9±1.3 | 0.024 |
| Visuospatial function score | 11.7±1.8 | 13.7±0.8 | 0.172 |
| GDS | 8.7±0.4 | 8.1±2.3 | 0.439 |
| APACHE II | 23.7±1.2 | 21.6±0.9 | 0.085 |
| SOFA | 8.0±0.4 | 8.0±1.0 | 0.500 |
| SAPS2 | 52.4±3.9 | 41.8±5.2 | 0.058 |
| GOSE-baseline | 6.4±0.5 | 6.7±0.3 | 0.327 |
| GOSE-3 months | 6.9±0.5 | 7.2±0.5 | 0.302 |
| GOSE-6 months | 7.3±0.4 | 7.4±0.5 | 0.457 |
| GOSE-12 months | 7.0±1.0 | 7.0±0.7 | 0.500 |
| Bacteremia present/absent | 3/4 | 1/13 | 0.049 |
| Steroid treatment present/absent | 3/4 | 6/8 | >0.999 |
| Septic shock present/absent | 6/1 | 11/3 | 0.694 |
| Delirium present/absent | 6/1 | 12/2 | >0.999 |
| Duration of septic shock (days) | 10.5±2.8 | 3.5±0.5 | 0.034 |
| Duration of mechanical ventilation (days) | 15.6±3.5 | 12.9±2.2 | 0.264 |
| Duration of sedation (days) | 15.6±3.4 | 12.6±1.6 | 0.229 |
| Duration of delirium (days) | 7.7±1.1 | 3.4±0.4 | 0.007 |
| Duration of hospitalization (days) | 52.9±5.1 | 36.6±3.7 | 0.012 |
Parametric data are presented as mean ± standard error.
*
Statistical assessment of parametric and non-parametric values is done by Mann-Whitney U and chi-square tests, respectively. Significant comparisons are denoted with bold characters.
MMSE, mini mental state examination; ACE-R, Addenbrook cognitive examination; GDS, geriatric depression scale; APACHE II, Acute physiology and chronic health evaluation II; SOFA, sequential organ failure assessment; SAPS2, simplified acute physiology score 2; GOSE, Glasgow outcome scale-extended.