Table 5.
Comparison of laboratory parameters of sepsis-induced brain dysfunction patients with and without cognitive impairment
| Biomarkers | MMSE <24 (n=7) | MMSE 24–30 (n=14) | p value |
|---|---|---|---|
| IL-1β (pg/mL) | 38.5±38.5 | 0.0±0.0 | 0.178 |
| IL-8 (pg/mL) | 66.9±53.5 | 52.9±36.0 | 0.416 |
| IL-6 (pg/mL) | 39.9±32.8 | 31.8±11.0 | 0.411 |
| IL-10 (pg/mL) | 5.6±4.8 | 1.5±0.6 | 0.213 |
| IFN-γ (pg/mL) | 4.1±2.9 | 4.4±1.8 | 0.460 |
| TNF-α (pg/mL) | 52.6±20.8 | 39.8±15.0 | 0.313 |
| IL-17 (pg/mL) | 1.5±0.7 | 1.7±0.7 | 0.426 |
| IL-12 (pg/mL) | 10.9±2.8 | 10.4±2.4 | 0.449 |
| Factor Bb (µg/mL) | 856.3±214.5 | 988.9±192.6 | 0.326 |
| C5a (ng/mL) | 19.3±8.8 | 13.7±3.4 | 0.282 |
| C4 d (µg/mL) | 2932.6±1527.7 | 2222.2±746.7 | 0.343 |
| iC3b (µg/mL) | 3.0±0.6 | 3.6±0.5 | 0.240 |
| Amyloid β (1–40) (ng/L) | 297.6±71.7 | 328.6±51.5 | 0.366 |
| Amyloid β (1–42) (ng/L) | 173.9±44.2 | 184.3±32.5 | 0.426 |
| Total tau (ng/L) | 16.0±3.5 | 19.6±3.6 | 0.245 |
| Phosphorylated tau (pg/mL) | 210.4±61.1 | 232.1±42.9 | 0.388 |
| S100b (pg/mL) | 106.9±54.7 | 20.0±9.3 | 0.083 |
| NSE (ng/mL) | 6.0±2.0 | 3.9±0.7 | 0.172 |
The values belong to 21 patients with cognitive assessment.
Data are presented as mean ± standard error.
Statistical assessment is done by Mann-Whitney U test.
Significant comparisons are denoted with bold characters.
MMSE, mini mental state examination; NSE, neuron specific enolase; S100b, S100 calcium-binding protein B.