Table 1.

Left ventricular (LV) function and dimensions were measured by serial echocardiography at 7, 13, and 19 weeks in wild-type (WT) and delta-like homologue 1-null (KO) mice

	7 weeks old			13 weeks old			19 weeks old
	WT	KO	P	WT	KO	P	WT	KO	P
	(n = 9)	(n = 10)		(n = 9)	(n = 10)		(n = 9)	(n = 9)a
IVSd (mm)	0.97 ± 0.03	0.91 ± 0.14	0.3078	1.00 ± 0.05	0.94 ± 0.13	0.1452	1.04 ± 0.07	0.90 ± 0.13	0.0378
LVIDd (mm)	2.94 ± 0.22	3.29 ± 0.37	0.0270	3.08 ± 0.18	3.7 ± 0.42	0.0011	3.24 ± 0.16	3.67 ± 0.22	0.0006
LVPWd (mm)	1.06 ± 0.04	1.09 ± 0.10	0.1055	1.07 ± 0.04	0.96 ± 0.08	0.0818	1.11 ± 0.07	0.98 ± 0.11	0.0244
IVSs (mm)	1.87 ± 0.09	1.76 ± 0.12	0.0442	1.83 ± 0.09	1.73 ± 0.16	0.1610	1.89 ± 0.09	1.74 ± 0.15	0.0328
LVIDs (mm)	1.05 ± 0.09	1.61 ± 0.26	0.0071	1.07 ± 0.13	1.82 ± 0.32	0.010	1.21 ± 0.13	1.8 ± 0.19	0.0001
LVPWs (mm)	1.84 ± 0.11	1.56 ± 0.31	0.0199	1.81 ± 0.31	1.53 ± 0.07	0.0222	1.82 ± 0.11	1.58 ± 0.13	0.0017
FS (%)	64.25 ± 1.40	51.21 ± 3.98	0.0001	65.3 ± 3.09	50.9 ± 4.36	0.0001	62.6 ± 2.78	51.05 ± 3.01	0.0003
Weight (g)	22.35 ± 1.19	22.43 ± 1.61	0.9104	26.7 ± 1.32	25.8 ± 1.7	0.5937	29.6 ± 1.87	28.0 ± 2.37	0.1341
Heart rate (bpm)	550.9 ± 29.05	543.8 ± 43.21	0.6802	533.65 ± 37.77	530.3 ± 37.44	0.8553	531 ± 54.61	525.3 ± 33.99	0.7984

FS, fractional shortening; IVSd/s, intraventricular septum thickness in diastole/systole; LVIDd/s, left ventricular end-diastolic/systolic diameter; LVPWd/s, LV posterior wall thickness in diastole/systole.

^aOne mouse unexpectedly died in the 19 weeks group. Two-tailed P-values are reported for each group. The echocardiography data were analysed with repeated measures ANOVA test. Data reported are mean ± SD.