Table 1.
7 weeks old |
13 weeks old |
19 weeks old |
|||||||
---|---|---|---|---|---|---|---|---|---|
WT | KO | P | WT | KO | P | WT | KO | P | |
(n = 9) | (n = 10) | (n = 9) | (n = 10) | (n = 9) | (n = 9)a | ||||
IVSd (mm) | 0.97 ± 0.03 | 0.91 ± 0.14 | 0.3078 | 1.00 ± 0.05 | 0.94 ± 0.13 | 0.1452 | 1.04 ± 0.07 | 0.90 ± 0.13 | 0.0378 |
LVIDd (mm) | 2.94 ± 0.22 | 3.29 ± 0.37 | 0.0270 | 3.08 ± 0.18 | 3.7 ± 0.42 | 0.0011 | 3.24 ± 0.16 | 3.67 ± 0.22 | 0.0006 |
LVPWd (mm) | 1.06 ± 0.04 | 1.09 ± 0.10 | 0.1055 | 1.07 ± 0.04 | 0.96 ± 0.08 | 0.0818 | 1.11 ± 0.07 | 0.98 ± 0.11 | 0.0244 |
IVSs (mm) | 1.87 ± 0.09 | 1.76 ± 0.12 | 0.0442 | 1.83 ± 0.09 | 1.73 ± 0.16 | 0.1610 | 1.89 ± 0.09 | 1.74 ± 0.15 | 0.0328 |
LVIDs (mm) | 1.05 ± 0.09 | 1.61 ± 0.26 | 0.0071 | 1.07 ± 0.13 | 1.82 ± 0.32 | 0.010 | 1.21 ± 0.13 | 1.8 ± 0.19 | 0.0001 |
LVPWs (mm) | 1.84 ± 0.11 | 1.56 ± 0.31 | 0.0199 | 1.81 ± 0.31 | 1.53 ± 0.07 | 0.0222 | 1.82 ± 0.11 | 1.58 ± 0.13 | 0.0017 |
FS (%) | 64.25 ± 1.40 | 51.21 ± 3.98 | 0.0001 | 65.3 ± 3.09 | 50.9 ± 4.36 | 0.0001 | 62.6 ± 2.78 | 51.05 ± 3.01 | 0.0003 |
Weight (g) | 22.35 ± 1.19 | 22.43 ± 1.61 | 0.9104 | 26.7 ± 1.32 | 25.8 ± 1.7 | 0.5937 | 29.6 ± 1.87 | 28.0 ± 2.37 | 0.1341 |
Heart rate (bpm) | 550.9 ± 29.05 | 543.8 ± 43.21 | 0.6802 | 533.65 ± 37.77 | 530.3 ± 37.44 | 0.8553 | 531 ± 54.61 | 525.3 ± 33.99 | 0.7984 |
FS, fractional shortening; IVSd/s, intraventricular septum thickness in diastole/systole; LVIDd/s, left ventricular end-diastolic/systolic diameter; LVPWd/s, LV posterior wall thickness in diastole/systole.
One mouse unexpectedly died in the 19 weeks group. Two-tailed P-values are reported for each group. The echocardiography data were analysed with repeated measures ANOVA test. Data reported are mean ± SD.