Table 3.
Hazard ratio of stomach cancer by talc exposure.
| Risk Factor | Person-Years (Cases) | Crude Hazard Ratio a | Adjusted Hazard Ratio b | Ten-Year Absolute Risk/1000 Persons (95% CI) | ||
|---|---|---|---|---|---|---|
| HR (95% CI) | p-Value | HR (95% CI) | p-Value | |||
| Exposure of talc | ||||||
| Unexposed period | 9,728,639 (1804) | 1.00 | 1.00 | 1.07 (0.99–1.15) | ||
| Talc-exposed period | 180,467 (45) | 1.83 (1.32–2.52) | <0.001 | 2.13 (1.54–2.94) | <0.001 | 1.95 (1.33–2.57) |
| Cumulative talc exposure | ||||||
| Low to none (≤6 g) | 9,774,552 (1816) | 1.00 | 1.00 | 1.07 (0.99–1.16) | ||
| Medium (6–21 g) | 87,550 (23) | 1.99 (1.28–3.09) | 0.002 | 2.30 (1.48–3.57) | <0.001 | 2.13 (1.19–3.07) |
| High (>21 g) | 47,004 (10) | 1.43 (0.71–2.87) | 0.31 | 1.58 (0.79–3.17) | 0.19 | 1.54 (0.47–2.60) |
Bold numbers: significant results. HR, hazard ratio. a The hazard ratios were estimated using the Cox proportional hazard model, with talc exposure treated as a time-dependent variable. b The adjusted hazard ratio was adjusted by age, gender, and Charlson Comorbidity Index (CCI) excluding malignancies.