Chromatographic methods [38,39] |
(+) |
Most sensitive and accurate method [40,41] |
(−) |
Very high acquisition and operating costs [40,41], especially for smaller companies |
(−) |
Well-trained operator necessary due to difficult handling of the method [40] |
Optical sensors [42,43] |
(+) |
Wide fields of application due to large measuring ranges (2–50 vol% [42], 5–50 vol% [43]) |
(−) |
High LoD (1.5 vol% [42], 2 vol% [43]) |
(−) |
Significant cross-sensitivity to pH [42] |
(−) |
Dye leaching over time possible [41] |
Microbial [44] and enzymatic [45] biosensor |
(+) |
Measuring range: 0.05–5 mmol/L [44], 0.1–5 mmol/L [45], after dilution also usable for alcoholic beverages [44,45] |
(−) |
Microbial and enzymatic activity depends on different factors (e.g., temperature [44,45], pH [45]) |
(−) |
Poor long-term stability due to loss of microbial and enzymatic activity over time [44,45] |
Hydrogel-based sensor (presented in this work) |
(+) |
Wide measuring range (up to 50 vol%) |
(+) |
Low LoD (0.060–0.56 vol%) |
(+) |
No relevant salt or pH cross-sensitivity |
(+) |
Low-cost sensor (~10€/Sensor) |
(+) |
Small size, even more miniaturizable |
(+) |
In-line process capability |
(−) |
Measurement uncertainty must be improved |