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. 2019 Mar 14;12:62. doi: 10.3389/fnmol.2019.00062

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Copyright © 2019 Wever, Largo-Barrientos, Hoekstra and Smidt.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Lmx1b expression is specifically lost in the Pitx3 positive domain of Lmx1b conditional knock-outs (cKOs) embryos. Analysis of Lmx1b and Pitx3 expression via in situ hybridization in embryonic day (E)14.5 midbrain sagittal sections. (A) When comparing the Pitx3Cre/+; Lmx1b L/L to the Pitx3Cre/+; Lmx1b+/+ a clear loss of Lmx1b is observed in the Pitx3 positive area (arrowheads). However Lmx1b expression is maintained in regions that are negative for Pitx3 (arrows). (B) Pitx3 expression seems unaffected. Scale bar = 300 μM.